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Materia Medica 2026

Apis Mellifica

Clinical Keynotes
HomeopathyUpchar.com

Clinical Profile

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General Characteristics

Top ↑

Apis Mellifica acts on cellular tissues causing edema of skin and mucous membranes.

Its characteristic effects resemble bee stings, providing accurate indications.

It causes swelling or puffing up of various parts, edema with a red, rosy hue.

#

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are key symptoms

Top ↑

Symptoms experience afternoon aggravation.

It causes Erysipelatous inflammations, dropsical effusions, and anasarca.

It causes Acute inflammation of kidneys and other parenchymatous tissues.

Apis Mellifica acts especially on outer parts, skin, coatings of inner organs, and serous membranes.

It produces serous inflammation with effusion: membranes of brain, heart, pleuritic effusion.

It causes Extreme sensitiveness to touch and general soreness.

It causes Constricted sensations.

It causes Sensation of stiffness and as if something torn off in the interior of the body.

It causes Much prostration.

It causes Thirstlessness, even in dropsical conditions.

Symptoms often alternate.

It causes Great lassitude and weariness.

It causes Puffiness under the eyes.

Complaints are often right-sided.

Shining tearfulness is present.

Jealously is present.

Fright is present.

Rage is present.

Vexation is present.

Grief is present.

The patient cannot concentrate mind when attempting to read or study.

Irritability and crossness are present; the patient is easily offended.

Indifference and apathy towards usual occupations are present.

Restlessness is present; the patient cannot remain in one place.

Sudden, shrill cries are present, especially in children (cerebral irritation).

Delirium with muttering is present.

Fear of death is present.

Forgetfulness and difficulty remembering recent events are present.

Suicidal thoughts are present, but the patient fears to carry them out.

The patient feels unfortunate and hopeless.

Headache as if head would burst

Top ↑

is present.

Headache is relieved by pressure.

Throbbing headache with heat and redness of the face is present.

Headache is better with cold applications.

Meningitis with shrill cries, grinding teeth, and head retracted

Top ↑

is present.

Vertigo is present, especially on closing eyes.

#

Edema of the eyelids, especially lower,

Top ↑

is present.

Stinging, burning pains in the eyes

Top ↑

are present.

Conjunctivitis with intense photophobia is present.

Lachrymation, hot and burning, is present.

Styes on the eyelids are present.

Dim vision is present.

Stinging pains in the ears are present.

Redness and swelling of the ears are present.

Otitis media, especially right-sided, is present.

Humming and buzzing in the ears are present.

Swelling and redness of the nose are present.

Stinging pains in the nose are present.

Coryza with watery discharge is present.

Nosebleeds are present.

Edema of the throat; feels constricted

Top ↑

is present.

Stinging, burning pains in the throat

Top ↑

are present.

#

Diphtheria with marked edema

Top ↑

is present.

Uvula is elongated and edematous.

Difficulty swallowing is present.

Difficult breathing and dyspnea are present.

#

Edema of the glottis

Top ↑

is present.

Dry, hacking cough is present.

Pleurisy with effusion is present.

Sensation of suffocation is present.

#

Pericarditis with effusion

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is present.

Palpitation of the heart is present.

Weakness and irregularity of the pulse are present.

Oppression of the chest is present.

# Stomach

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Thirstlessness.

Nausea and vomiting are present.

Abdomen is tender and swollen

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Ascites is present.

Ovaries are enlarged and sensitive.

#

Rectum:

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Diarrhea, watery and involuntary, is present.

Hemorrhoids, swollen and painful, are present.

Scanty, dark-colored urine is present.

Albuminuria is present.

#

Acute nephritis

Top ↑

is present.

Burning pain on urination is present.

Frequent urging to urinate is present.

Involuntary urination is present.

Ovaries are swollen and sensitive to touch.

Ovarian cysts are present.

Stinging pains in the ovaries are present.

Menses are suppressed.

Metritis with stinging pains is present.

Leucorrhea, acrid and burning, is present.

Erysipelas of the genitals is present.

Musculoskeletal

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Edema of the extremities is present.

Stinging pains in the joints are present.

Rheumatism with swelling and redness is present.

#

Urticaria with intense itching and stinging

Top ↑

is present.

Skin eruptions that sting are present.

Carbuncles are present.

Restless sleep is present.

Sleeplessness with mental activity is present.

Worse (<)

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Heat in any form; warm room; touch; pressure; afternoon; lying down; right side.

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Heat (burning symptoms)

Touch or pressure (though head is > by pressure)

Heated rooms

Warmth of bed

Night (eyes and chest)

Lying down

Morning (mucus in mouth, restlessness, diarrhea)

Evening (erysipelas, giddiness, headache, chills, fever)

#

Better (>)

Top ↑

Open air; cold applications; uncovering; motion.

Compare: Apium virus (auto-toxemia, with pus products); Zinc; Cantharis; Vespa; Lachesis; Natrum muriaticum; Urtica urens; Belladonna.

Antidotes: Vinegar, Ledum, Natrum muriaticum, Camphor.

Complementary: Natrum muriaticum, Calcarea carbonica.

Useful in: Allergies, angioedema, bee stings, burns, cystitis, diphtheria, erysipelas, glomerulonephritis, hives, insect bites, mastitis, meningitis, ovarian cysts, pericarditis, pharyngitis, pleurisy, rheumatism, tonsillitis, urticaria.

Cold water

Sitting

Compare: Vespa and serpent poisons. Acet. ac. (dropsy); Aco.; Anac. (urticaria); Apoc. can. (dropsy); Arn. (bruised, sore conditions); Ars. (typhoid, gangrene, dropsies, scarlatina, urticaria, chills); Bell. (meningitis, sore throat, erysipelas, scarlatina); Brom. (swelling of ovary during menses); Bry. (meningitis, rheumatism); Canth. (burns, erysipelas, urinary symptoms); Chi.; Colch.; Crot. t. (urticaria); Euphras. (conjunctiva); Fer.; Graph.; Hep.; Hyo.; Iod. (synovitis); Lach.; Lyc.; Merc. Nat. ars.; Nat. mur. (chills, urticaria, tension in ovarian region) Puls.; Rhus (eyes; but Apis has less tendency to suppuration; vesicular erysipelas but darker than Apis and spreading left to right─Apis right to left; typhoid, restlessness, but Apis is more fidgetiness); Rumex (painless, greenish-yellow morning diarrhea); Sabi.; Sep.; Silic. (ovarian affections with inverted nipples; ulcer on tongue; vaccination effects); Urt. ur.; Zn.

Antidotes: Nat. mur. in all forms; sweet oil; onions; Ammonia; Ipec., low. (also powdered Ipec. applied locally) Lach.; Ledum.

It antidotes: Canth., Iod., Chi., Dig.

It follows well: Bry. (when cephalic cry appears); Helleb. (when torpor sets in); Iod., Hep., Merc., Lyc., Sul.

Is followed well by: Graph. (tetter on ear lobe); Kali bi. (scrofulous ophthalmia); Arsen. (hydro-thorax); Phos. (diphtheria); Stram. (mania); Lyc. (staphyloma); Sul. (hydrothorax, pleurisy, hydrocephalus); Iod. (swollen knee).

Complementary: Nat. mur. (the "chronic" of Apis).

Inimical: Rhus in eruptive diseases.

Apis Mellifica

Top ↑

_Apium virus. Honey-bee poison. N. O. Insecta._

Tinctures are made of the whole bee and of dilutions of the poison with alcohol.

Burning, stinging, lancinating pains with excessive swelling (like a bee sting)

Top ↑

Great sensitiveness of the surface to touch.

General soreness: "every hair is painful to contact."

Great debility as if he had worked hard; compelled to lie down.

Tired and bruised feeling.

Great restlessness and fidgetiness.

Trembling, jerking, and twitching.

One half of the body twitching, the other lame or paralyzed. Hemiplegia.

More a right-side medicine; symptoms proceed from right to left (Rhus left to right) and from above downwards.

Stiffness of lower jaw, extending to tongue and throat, rendering speech difficult, with constriction.

Difficulty in breathing, especially inspiration.

Terrible restlessness.

Dyspnea, face purple, head thrown back.

Violent, deep, hard, ringing cough, excited by constrictive feeling in the throat, reaching down to sore place in the lungs.

Slow action, do not change too soon. Increased flow of urine shows favorable effect.

Dropsies characterized by a waxy hue of skin, whitish or yellowish; transparent swelling of eyelids; bag-like swelling under eyes; surface of body sore, bruised, or burning.

Cardiac dropsy: feet swell after walking, intolerably sore and burning.

Chest affections: sensation of contraction and inability to lie down.

Tension, swelling, and stiffness of limbs.

Sensation in abdomen as if something tight would break if too much effort was made to void a constipated stool.

Aversion to tight things.

Prostration even to faintness. Paralytic weakness. Paralysis (after diphtheria and other severe diseases).

Nervous, restless, over-sensitive; or hot and drowsy, with or without thirst.

Sudden "puffing up" of the whole body.

Complete anasarca, no thirst, pale, waxy, almost transparent.

Burning, stinging pains, like bee-stings, occurring occasionally.

Great sensitiveness to touch and pressure (abdomen).

Clonic and tonic spasms.

Sudden weakness with coldness.

Tension (over the eyes in the left side of head) behind the ears, in the neck.

Dark hemorrhages.

Tired, as if bruised in every limb, and esp. in the back, as after exertion; worse on rising after sitting.

Brain feels paralyzed.

Impaired memory.

Absent-minded.

Cannot concentrate thought.

Indifference.

Torpor and apathy.

Awkward, lets things fall and laughs sillily at the mishap.

Loss of consciousness.

Great tearfulness; cannot help crying.

Children constantly whining.

Screaming, sudden outcry during sleep.

Busy, restless, continually changing his occupation.

Cannot bear to be left alone.

Hysteria.

In women: jealousy; mania from sexual irritation.

Depression, feels as if about to die (without fear of death).

Delirium, low muttering; after suppressed scarlet eruption.

Irritation.

Premonition of death.

Dread of death; sensation as if he could not breathe again.

Fear of being poisoned.

Giddiness: when sitting, standing, lying, when closing the eyes; with nausea and headache.

Congestion to the head, with suppressed menstruation.

Pressing pain in forehead and temples; < rising; in warm bed; > pressing the forehead together.

Brain feels tired.

Sudden stabbing and stinging pains.

Aching in left temple.

Hydrocephalus in children and apoplexy in old persons.

Hydrocephalus: scalp very sensitive; copious sweat of head; child lies in torpor, delirium interrupted by shrill cries, boring head deep in pillow, rolls it from side to side.

Convulsions on one side of the body, paralyzed the other; squinting, grinding of teeth, urine scanty.

Burning, stinging, shooting, piercing pains in and about the eyes.

Aching over right eye extending to right eyeball.

Twitching of eyeballs.

Staphyloma.

Cornea thick, having dark, smoky spots; greyish, smoky, opaque.

Keratitis.

Conjunctiva reddened, chemosed, lids everted.

Sensation of mucus in the eyes.

Itching in eyes and lachrymation.

Weakness of the eyes, with pain, photophobia, and increased secretions.

Agglutination of the lids.

Edematous swelling of eyelids; bags under eyes; upper lids hang over like sacs

Top ↑

Styes with stinging pains; smoky darkness before the eyes.

Redness and swelling of both ears.

Erysipelas; otitis after scarlatina; hardness of hearing.

Swollen, red, edematous.

Coryza, worse from warmth; chronic catarrh with crusty nostrils; polypus.

Edematous swelling of the face; red and hot, swollen so as to be unrecognizable, with piercing and burning pain; waxy, pale.

Happy expression of face; or terror; or apathy.

Burning, stinging heat in the face with purple color.

Erysipelas of the face.

Erysipelas of the face, with fever, coated tongue.

Erysipelas going right to left.

Jaws stiff, with stiff tongue and impossibility of intelligible speech.

#

Teeth:

Top ↑

Grinding of the teeth; sudden and involuntary biting them together; covered with yellow mucus or brown sordes.

Mouth

Top ↑

Lips edematous; upper lip swollen, hot and red.

Mouth red, burning, stinging, scalding.

Dryness of tongue, mouth, and throat; fiery redness of buccal cavity, with painful tenderness.

Dry, swollen, inflamed tongue, with inability to swallow.

White, dry tongue (with diarrhea).

Tongue: can hardly be protruded; hangs from the mouth; cancer of.

Swollen tongue; shining.

Borders blistered; feel as if scalded and quite raw.

Ulcer in left border.

Tongue swollen, dry, cracked, sore, ulcerated, or covered with vesicles.

Viscid, tough, frothy, saliva.

Gums sacculated and look watery.

Fetor of breath, with headache.

Throat

Top ↑

Throat has appearance as if stung.

Dryness in the throat with heat, without thirst.

Burning, stinging in throat.

Erysipelatous; Glossy red varnish.

Inflammation of the throat, with swelling, redness, and stinging pains.

Ulcerated sore throat (in scarlet fever, when the eruption does not come out).

Diphtheritic sore throat gets well as a scarlatina rash develops.

Throat swollen inside and outside; hoarse, sense of constriction; breathing and swallowing difficult.

Ulcers on the tonsils, palate, etc.

Uvula long and dropsical.

Sensation of foreign body or fishbone in the throat; of constriction.

Paralysis.

# Respiratory Organs

Top ↑

Irritation to cough in the supra-sternal fossa.

Hoarseness.

Hoarseness in the morning.

Respiration hurried and difficult (with fever and headache).

Edema glottidis.

Asthma; worse in cold weather.

Croupy cough.

Obstinate night cough from 9 p.m. to 4 a.m.

Cough which loosens with difficulty, rouses from sleep before midnight and ceases as soon as least particle is loosened, which is swallowed.

Feeling of constriction causing a single, spasmodic, hacking cough at short intervals.

Violent cough, deep, hard ringing; incessant for three hours; excited by constricted feeling in throat, but reaching down to lungs, the upper part of which are very sore and sensitive.

Dyspnea; especially difficult inspiration.

Chest

Top ↑

Hydrothorax.

Sensation of soreness in the chest, as from a bruise.

Oppression of the chest, shortness of breath, esp. when ascending; inability to remain in a warm room.

Dull, aching pain in the left side of the chest, near the middle of the sternum, with sensation of fullness in the chest and short breath.

Expectoration of copious, transparent, frothy, bloody mucus.

Stitches in left side of chest and through back.

Burning, stinging pain through entire front of chest.

Melting in region of diaphragm, as from running violently.

Every shock from coughing gives pain in the head and some pain through the chest, as from the clavicle; > after loosening a small portion of mucus, or a large quantity of transparent: frothy, and bloody mucus is expectorated.

Heart

Top ↑

Sudden pain just below the heart, soon extending toward right chest, with suffocation.

Very feeble action of the heart; violent beats, shaking the whole body; intermittent beats.

Region of heart sensitive to least pressure; rasping sounds of systole and diastole unmistakably audible.

Palpitation of heart from scanty secretion of urine, perfectly cured by establishing the natural quantity.

Pulse: almost imperceptible at wrist; accelerated and full; very frequent and hard; wiry; irregular and slow pulse; intermittent.

Stomach

Top ↑

No thirst with the heat.

Thirstlessness (with dropsy).

Vomiting of bile.

Vomiting, with inflammation of the stomach.

Vomiting, with diarrhea.

Burning heat in the stomach.

Great soreness in pit of stomach when touched.

Violent pain and sensitiveness in region of stomach.

Abdomen

Top ↑

Great sensitiveness of the abdomen to touch.

Soreness of the bowels and abdominal walls; mornings when sneezing or pressing upon them.

Sensitiveness of epigastrium and whole abdomen to touch; of right inguinal region; across hypogastrium from ilium to ilium.

Pain in abdomen on pressure, touch and horizontal position, with sensitiveness.

Peritonitis.

Erysipelas from contusion.

Rumbling and meteoric distension.

Ascites and anasarca.

Hard swelling in the right groin, oblong, as large as a cucumber.

Long-standing inguinal hernia.

Collapse of abdominal walls in meningitis infantum.

Stool and Anus

Top ↑

Sensation of rawness in the anus, with diarrhea.

Discharge of flatus before stool.

Diarrhea: during fevers; from heat; in debilitated children; from irritability of brain (hydrocephaloid).

Diarrhea, yellowish-green, with mucus, especially in the morning.

Stool thin, watery, yellow, < in morning; may or may not be offensive.

Stools smelling very offensively.

Diarrhea and vomiting.

Diarrhea is copious, blackish-brown, green, or whitish; orange-colored; greenish, yellow mucus; yellow watery; soft and pappy, mixed with serum; thin yellow.

At every motion of body bowels act as though he had no power.

Uncertain anus; constantly open (during urination), oozing of liquid.

Swelling of anus.

Hemorrhoids, with stinging pains.

Constipation, with feeling as if something would break if he continued to strain.

Stools involuntary and painless, or painful and urging, olive-green, profuse, and full of red lumps, like chopped beets; bloody, painless; smell brassy or like carrion; very offensive.

Protruding varices, which sting, burn, and smart intolerably.

#

Urinary Organs:

Top ↑

Burning soreness when urinating.

Strangury.

Pain in region of kidneys; soreness on pressure or when stooping.

Frequent desire, with passage of only a few drops.

Urine scanty and high-colored; with thirstlessness.

Incontinence of urine from coughing and other circumstances.

Urine suppressed.

Too profuse discharge of urine.

Frequent and profuse urination.

Albuminuria of scarlatina.

Increase of urine under Apis shows that the medicine is acting well.

Burning and stinging in the urethra.

Burning and smarting in the urethra, as if it were scalded.

Bladder very painful, often tenesmus after urinating.

Urine often bloody, milky appearance; very dark and frothy; very fetid; sediment reddish-brown, like coffee grounds.

Male Sexual Organs

Top ↑

Sexual desire increased.

Chancre with stinging pains like bee-stings, and with a highly inflamed circumference.

Pains and swellings of testes and prostate.

Dropsy of the scrotum and prepuce; hydrocele.

Female Sexual Organs

Top ↑

Amenorrhea or menorrhagia.

Inflammation, induration, swelling, and dropsy of the ovaries (right).

Weight and pain in either ovarian region, predominantly right side.

Ovaries feel better by lying on right side.

Enlargement of the right ovary with pain in the left pectoral region and cough.

Sharp, cutting, stinging pain in the swollen (right) ovary; worse during menstruation.

Ovarian tumors, with stinging pains like bee-stings.

Metritis, peritonitis, with stinging, thrusting pains.

Pressing-down pain in the uterus.

Bearing-down, with sensation as before menses.

Dropsy of the ovaries (right); dropsy of the uterus.

Strained pain left ovary.

Menstruation suppressed or diminished, with congestion to the head.

Labor-like, bearing-down pains, followed by dark, bloody mucus.

Threatened miscarriage in the early months, with heaviness of the abdomen, restlessness, and yawning.

Abortion during the early months.

Dropsy in the latter part of pregnancy attended with puerperal convulsions.

Ulceration and engorgement of os uteri.

Large and painful swelling of the labia, with heat and stinging pains.

Erysipelatous inflammation of the breasts.

Swelling and hardness of the mammae threatening to ulcerate.

Scirrhus or open cancer of the mammae, with stinging, burning pains.

Rheumatic pain in back and limbs.

Cerebro-spinal meningitis.

Tired, as if bruised in the back, as after exertion; worse on rising after sitting.

#

Upper Limbs:

Top ↑

Hands bluish, and inclined to be cold.

Edema of the hands.

Sensation of numbness in fingers, especially the tips about the roots of nails.

Panaritium with burning, stinging, and throbbing, very sensitive to touch.

#

Lower Limbs:

Top ↑

Cold legs.

Sensation in the toes and whole foot, as if too large; swollen and stiff.

Legs (ankles) and feet waxy, pale, and edematous.

Burning in the toes with redness; feet cold.

Suppressed perspiration of the feet.

Numbness and coldness of feet, even paralysis.

Dropsy of limbs in diphtheritic albuminuria.

Puffy swelling of the knees.

Edematous swellings.

Skin usually white, almost transparent (ovarian dropsy).

Hives.

#

Urticaria like bee-stings, or stings from other insects, with intolerable itching at night

Top ↑

Carbuncles, with burning, stinging pains.

Eruption like nettle-rash over the whole body.

Erysipelas; with gangrenous spots.

Swelling and dry erysipelatous redness.

Scarlet eruptions.

Body covered with large, elevated, white wheals.

Panaritium (burning, stinging).

Boils and swellings of all descriptions with stinging pains.

Sleep

Top ↑

Much yawning.

Great desire to sleep; extreme sleepiness.

Sleep disturbed by many dreams.

Dreams full of care and toil; of making long journeys; of flying through the air; of hot stones; of walking over hot floors; of walking a long way over wet roads.

Sleep, late in the morning.

Awakens from sleep with a shrill shriek (child suffering from hydrocephalus).

Fever

Top ↑

Pulse full and rapid; small and trembling; intermitting.

Chill, mostly towards the evening (3-4 p.m.).

Chilliness from the least movement, with heat of the face and hands; runs down the back with great prostration.

During hot stage more or less violent headache; generally a continuous deep sleep.

Heat with thirst, wishes to uncover.

Dry heat towards evening with sleepiness.

Sweating stage either absent or of a very light grade.

Sensation of heat is more felt about the pit of the stomach and in the chest.

Perspiration, alternating with dryness of the skin.

Much burning of the skin on various parts of the body.

Thirst wanting during sweat; may or may not be present during heat; always thirst during chill.

Sweat after trembling and fainting, then nettlerash.

After the fever paroxysm, sleep.

Apyrexia: urine scanty; feet swollen; limbs sore; restless; urticaria.

Causation

Top ↑

Grief.

Fright.

Rage.

Vexation.

Jealousy. (The queen bee is the most jealous thing in nature.)

Hearing bad news, mental shock.

Suppressed eruptions.

Clinical Applications:

Top ↑

Abscess

Ankles, swelling of

Apoplexy

Asthma

Bladder affections

Bright's disease

Carbuncle

Chancre

Constipation (especially in sucklings)

Diarrhea

Diphtheria

Dissection wounds

Dropsy

Ear, erysipelas of

Erysipelas

Erythema nodosum

Eyes, affections of; optic neuritis

Feet, burning of

Gangrene

Gout

Hands, swelling of

Heart affections

Heat-spots

Housemaid's knee

Hydrocephalus

Hydrothorax

Injuries

Intermittent fever

Irritation

Jealousy, effects of

Joints, synovitis

Kidney affections

Labia, inflammation of

Laryngitis

Lichen

Meningitis

Menstruation, derangements of

Nettle-rash

Nose, redness of

Operations, effects of

Ovaries, pain in; inflammation of; tumors of

Panaritium

Pannus

Peritonitis

Phlebitis

Pleurisy

Prostatitis

Punctured wounds

Red-gum

Rheumatism

Scarlatina

Self-abuse

Suppressed eruptions, effects of

Sycosis

Syphilis

Throat, sore

Tongue, edema of; ulceration of

Trachea, irritation of

Tumors

Typhus

Urethritis

Urine, abnormalities of

Vaccination

Varicose veins

Variola

Wounds

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